Steroid Metabolomic Disease Signature of Nonsyndromic Childhood Obesity

Global metabolomic profiling targeting childhood obesity in the Hispanic population.

BACKGROUND Metabolomics may unravel important biological pathways involved in the pathophysiology of childhood obesity. OBJECTIVES We aimed to 1) identify metabolites that differ significantly between nonobese and obese Hispanic children; 2) collapse metabolites into principal components (PCs) associated with obesity and metabolic risk, specifically hyperinsulinemia, hypertriglyceridemia, hyp...

Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease

Infection of human skin with Mycobacterium ulcerans, the causative agent of Buruli ulcer, is associated with the systemic diffusion of a bacterial macrolide named mycolactone. Patients with progressive disease show alterations in their serum proteome, likely reflecting the inhibition of secreted protein production by mycolactone at the cellular level. Here, we used semi-quantitative metabolomic...

Disease risks of childhood obesity in China.

OBJECTIVE To estimate the relative risks of dyslipidemia, hypertension, diabetes mellitus, and metabolic syndromes among overweight and obese Chinese children compared with their normal weight counterparts. METHODS Overweight and obesity were defined by age- and sex-specific BMI classification reference for Chinese children and adolescents. Pediatric metabolic syndrome (MetS) and each risk fa...

Adverse childhood experiences, obesity, and liver disease.

Childhood obesity and coronary heart disease.

n engl j med 365;20 nejm.org november 17, 2011 1927 and effectiveness with active surveillance if this vaccine is deployed. What does this vaccine mean for the future of the control and elimination of malaria? The considerable increase in global funding is paying dividends. In places where effective interventions (insecticide-treated bed nets, insecticides, and artemisinin-combination treatment...